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KMID : 0390320110210020057
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Chungbuk Medical Journal
2011 Volume.21 No. 2 p.57 ~ p.62
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Correlation between serum ferritin and C-Reactive Protein level in patients with anemia of acute infection
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Shin Kyeong-Seob
Son Bo-Ra
Ji Il-Woon
Yun Seok-Joong
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Abstract
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Purpose: The acute phase response and anemia of acute infection are characterized by hypoferrinemia associated with an increased ferritin synthesis, which is mediated by the activated inflammatory cytokines. The aim of our study is to evaluate the correlation between serum ferritin and C-reactive protein (CRP) and to distinguish iron deficiency anemia from anemia of acute infection.
Material and Methods: We studied 76 subjects, who were tested serum ferritin and hCRP at the same time at Chungbuk National University Hospital. They were subdivided according to hCRP levels, resulting in 44 patients with normal (0-3 mg/dL) and 32 patients with elevated (>3 mg/dL) hCRP groups.
Results: In the total hCRP group, the ferritin level showed a positive correlation with hCRP level. In the normal hCRP group, the ferritin and hCRP level didn’t have any significant correlation. In the elevated hCRP group, the ferritin and hCRP level have significant correlation.
Conclusion: The ferritin levels in acute infectious state were markedly increased in some cases. The ferritin follow-up inspection is necessary for discriminating between iron deficiency anemia and anemia of acute infection.
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KEYWORD
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Acute Infection, Anemia, Ferritin, CRP
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